Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.68 |
| ▸ | PDE4A | P27815 | 15/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7053217 | 0.99 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4CRAB9A | |
| SCHEMBL7051138 | 0.89 | PDE4B (0.66) | PDE4BPDE4DPDE4APDE4CRAB9A | |
| SCHEMBL7049405 | 0.83 | PDE4A (0.59) | PDE4BPDE4DPDE4APDE4CRAB9A | |
| SCHEMBL7050573 | 0.82 | PDE4A (0.61) | PDE4BPDE4DPDE4APDE4CKMT2A | |
| SCHEMBL7050561 | 0.81 | PDE4D (1.00) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5722911 | 0.80 | PDE4D (0.56) | PDE4BPDE4DPDE4APDE4CRAB9A | |
| SCHEMBL7055897 | 0.80 | PDE4A (0.53) | PDE4BPDE4DPDE4APDE4CMAPT | |
| SCHEMBL6839328 | 0.78 | SMN1; SMN2 (0.62) | PDE4BPDE4DPDE4APDE4CRAB9A | |
| SCHEMBL6837653 | 0.76 | SMN1; SMN2 (0.60) | PDE4BPDE4DPDE4APDE4CRAB9A | |
| SCHEMBL7050574 | 0.75 | RAB9A (0.78) | PDE4BPDE4DPDE4APDE4CRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5972936-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVER LIMITED (GB) | 1999-10-26 | — | — | US | disclosed |
| US-5925636-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVERY LIMITED (GB) | 1999-07-20 | — | — | US | disclosed |
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |