Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.78 |
| ▸ | NPC1 | O15118 | 2/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723065 | 0.88 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16581094 | 0.84 | RAB9A (0.79) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11107533 | 0.84 | RAB9A (0.79) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6837407 | 0.80 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL978037 | 0.79 | LMNA (0.77) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL219813 | 0.79 | LMNA (1.00) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7053276 | 0.79 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5584678 | 0.77 | LMNA (0.75) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3614366 | 0.77 | LMNA (0.75) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4209809 | 0.77 | LMNA (0.75) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5972936-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVER LIMITED (GB) | 1999-10-26 | — | — | US | disclosed |
| US-5925636-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVERY LIMITED (GB) | 1999-07-20 | — | — | US | disclosed |
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |