Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053361 | 0.90 | NR3C1 (0.53) | NR3C1HPGDLMNAMAPTKMT2A | |
| SCHEMBL7051611 | 0.89 | NR3C1 (0.51) | NR3C1HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7048724 | 0.89 | NR3C1 (0.65) | NR3C1HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7050898 | 0.88 | NR3C1 (0.54) | NR3C1HPGDLMNAMAPTKMT2A | |
| SCHEMBL7053515 | 0.86 | NR3C1 (0.72) | NR3C1HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7052325 | 0.85 | NR3C1 (0.84) | NR3C1HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7054883 | 0.85 | NR3C1 (0.60) | NR3C1HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL27565370 | 0.83 | NR3C1 (0.66) | NR3C1HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7054388 | 0.81 | NR3C1 (0.55) | NR3C1HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7052042 | 0.79 | THRA (0.59) | NR3C1HPGDLMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |