Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | BCL2 | P10415 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050898 | 0.91 | NR3C1 (0.54) | NR3C1PTGS1PTGS2MAPTLMNA | |
| SCHEMBL7054388 | 0.91 | NR3C1 (0.55) | NR3C1PTGS1PTGS2MAPTLMNA | |
| SCHEMBL7050581 | 0.90 | NR3C1 (0.63) | NR3C1PTGS1PTGS2MAPTLMNA | |
| SCHEMBL7056281 | 0.82 | NR3C1 (0.56) | NR3C1PTGS1PTGS2MAPTLMNA | |
| SCHEMBL7048724 | 0.81 | NR3C1 (0.65) | NR3C1PTGS1PTGS2MAPTLMNA | |
| SCHEMBL7051611 | 0.79 | NR3C1 (0.51) | NR3C1MAPTLMNAKDM4EHSD17B10 | |
| SCHEMBL7053515 | 0.78 | NR3C1 (0.72) | NR3C1MAPTLMNAKMT2AGFER | |
| SCHEMBL7052325 | 0.78 | NR3C1 (0.84) | NR3C1HPGD | |
| SCHEMBL7054883 | 0.77 | NR3C1 (0.60) | NR3C1PTGS1PTGS2MAPTLMNA | |
| SCHEMBL4962636 | 0.77 | THRB (0.56) | NR3C1MAPTLMNAKMT2AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |
| CN-1311767-A | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KAROBIO AB (SE) | 2001-09-05 | — | — | CN | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |