Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531735 | 0.88 | SMN1; SMN2 (0.69) | KMT2AGLASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL12773610 | 0.86 | SMN1; SMN2 (0.75) | KMT2AGLASMN1; SMN2PTPN1POLB | |
| SCHEMBL6477394 | 0.86 | CNR1 (0.54) | KMT2AGLASMN1; SMN2MEN1 | |
| SCHEMBL6476422 | 0.84 | MTNR1A (0.63) | SMN1; SMN2 | |
| SCHEMBL6482686 | 0.84 | HDAC3 (0.64) | KMT2ASMN1; SMN2MAPTPOLBMEN1 | |
| SCHEMBL793998 | 0.84 | GLA (1.00) | KMT2AGLASMN1; SMN2MAPTLMNA | |
| SCHEMBL9853024 | 0.83 | SMN1; SMN2 (0.71) | KMT2AGLASMN1; SMN2PTPN1POLB | |
| SCHEMBL6484083 | 0.82 | KMT2A (0.62) | KMT2ASMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL6530877 | 0.82 | SMN1; SMN2 (0.69) | KMT2AGLASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL6023129 | 0.81 | BCHE (0.54) | KMT2APOLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003014115-A1 | 3-SUBSTITUTED PYRROLO (2.1-A) ISOQUINOLINE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2003-02-20 | — | — | WO | disclosed |
| WO-2003014117-A1 | 3-SUBSTITUTED PYRROLO[2.1-A]ISOQUINOLINE DERIVATIVES | BAYER CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |