Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819716 | 0.89 | GABRP (0.44) | L3MBTL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30968742 | 0.89 | GABRP (0.44) | L3MBTL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28276724 | 0.88 | GABRP (0.43) | L3MBTL1GABRPGABRDGABRA1GABRB1 | |
| Nitric Acid SCHEMBL7049249 | 0.80 | GABRP (0.40) | L3MBTL1POLBGABRPGABRDGABRA1 | |
| SCHEMBL2487071 | 0.78 | ATM (0.46) | L3MBTL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29619749 | 0.78 | ATM (0.46) | L3MBTL1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10574606 | 0.78 | GABRP (0.36) | L3MBTL1GABRPGABRDGABRA1GABRB1 | |
| Nitric Acid SCHEMBL7048263 | 0.76 | KDM4E (0.34) | L3MBTL1POLBGABRPGABRDGABRA1 | |
| Nitric Acid SCHEMBL7047310 | 0.76 | KDM4E (0.34) | L3MBTL1POLBGABRPGABRDGABRA1 | |
| Nitric Acid SCHEMBL7052214 | 0.76 | PKM (0.37) | L3MBTL1POLBGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601288-B1 | Substituted 2,3-dicarboxypyridinium nitrates | BASF AG (DE) | 2003-05-02 | — | — | EP | claimed |
| EP-0601288-A2 | Substituted 2,3-dicarboxypyridinium nitrates | AMERICAN CYANAMID COMPANY (US) | 1994-06-15 | — | — | EP | claimed |
| US-5284955-A | Herbicide intermediates | AMERICAN CYANAMID COMPANY (US) | 1994-02-08 | — | — | US | claimed |