Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | AGER | Q15109 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.33 |
| ▸ | ASPH | Q12797 | 4/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487883 | 0.91 | KDM4E (0.40) | KDM4EALDH1A1TSHRL3MBTL1CYP3A4 | |
| Nitric Acid SCHEMBL7047310 | 0.85 | KDM4E (0.34) | KDM4EALDH1A1TSHRL3MBTL1CYP3A4 | |
| Nitric Acid SCHEMBL7049249 | 0.85 | GABRP (0.40) | KDM4EALDH1A1TSHRL3MBTL1CYP3A4 | |
| Nitric Acid SCHEMBL7052214 | 0.81 | PKM (0.37) | KDM4EALDH1A1TSHRL3MBTL1CYP3A4 | |
| SCHEMBL12224094 | 0.80 | SIRT6 (0.37) | KDM4EALDH1A1TSHRASPHKDM8 | |
| SCHEMBL28281331 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1TSHRL3MBTL1CYP3A4 | |
| SCHEMBL9317147 | 0.78 | ALDH1A1 (0.33) | KDM4EALDH1A1ASPHKDM8POLB | |
| SCHEMBL9315383 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1TSHRL3MBTL1CYP3A4 | |
| Nitric Acid SCHEMBL7051650 | 0.76 | L3MBTL1 (0.38) | KDM4EALDH1A1TSHRL3MBTL1CYP3A4 | |
| SCHEMBL2486333 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1TSHRL3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601288-B1 | Substituted 2,3-dicarboxypyridinium nitrates | BASF AG (DE) | 2003-05-02 | — | — | EP | claimed |
| EP-0601288-A2 | Substituted 2,3-dicarboxypyridinium nitrates | AMERICAN CYANAMID COMPANY (US) | 1994-06-15 | — | — | EP | claimed |
| US-5284955-A | Herbicide intermediates | AMERICAN CYANAMID COMPANY (US) | 1994-02-08 | — | — | US | claimed |