Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056215 | 0.90 | PDE4A (0.49) | PDE10ASMN1; SMN2P2RX7KMT2APOLB | |
| SCHEMBL7055640 | 0.87 | LMNA (0.58) | PDE10ASMN1; SMN2KMT2APOLBALDH1A1 | |
| SCHEMBL7055521 | 0.82 | PDE4A (0.53) | PDE10AKMT2APOLBALDH1A1LMNA | |
| SCHEMBL7058533 | 0.82 | ALDH1A1 (0.55) | PDE10ASMN1; SMN2KMT2APOLBALDH1A1 | |
| SCHEMBL7051834 | 0.80 | PDE4A (0.65) | KMT2APOLBALDH1A1LMNAMEN1 | |
| SCHEMBL7051848 | 0.80 | PDE4A (0.67) | PDE10ASMN1; SMN2TP53POLBALDH1A1 | |
| SCHEMBL7056153 | 0.80 | ALDH1A1 (0.56) | PDE10ASMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL7054222 | 0.78 | PDE4A (0.58) | SMN1; SMN2KMT2APOLBALDH1A1LMNA | |
| SCHEMBL11800723 | 0.77 | CHRM1 (0.48) | KMT2APOLBALDH1A1LMNAMEN1 | |
| SCHEMBL7050618 | 0.76 | PDE4A (0.49) | PDE10ASMN1; SMN2KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841929-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-07 | — | — | EP | claimed |