Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL15059718 | 0.97 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2TSHRHTTLMNA | |
| Tetrahydrofuran SCHEMBL27898407 | 0.97 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2TSHRHTTLMNA | |
| Tetrahydrofuran SCHEMBL27918528 | 0.97 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2TSHRHTTLMNA | |
| Dioxane SCHEMBL15059720 | 0.88 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2TSHRHTTLMNA | |
| Tetrahydrofuran SCHEMBL30232 | 0.88 | — | — | |
| Tetrahydrofuran SCHEMBL8412489 | 0.88 | ALDH1A1 (0.57) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL165529 | 0.88 | — | — | |
| Tetrahydrofuran SCHEMBL28302889 | 0.87 | CA1 (0.43) | ALDH1A1SMN1; SMN2TSHRHTTLMNA | |
| Tetrahydrofuran SCHEMBL27898672 | 0.87 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL28295154 | 0.86 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2TSHRHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715616-A | Surfactant system for crystallizing organic compounds | 诺华股份有限公司 | 2019-05-03 | — | — | CN | claimed |
| CN-101041664-B | Preparation of cefepime halogen acid salt by calcium salt precipitation process | SHENZHEN SALUBRIS PHARM CO LTD | 2010-05-26 | — | — | CN | disclosed |
| CN-100560588-C | Preparation of cefepime hydrochlorice by sodium salt precipitation method | XINLITAI PHARMACEUTICAL CO LTD (CN) | 2009-11-18 | — | — | CN | disclosed |
| CN-101397304-A | Method for preparing high-purity cefpirome sulfate by sodium salt precipitation method | SHENZHEN SALUBRIS PHARMACEUTIC (CN) | 2009-04-01 | — | — | CN | disclosed |
| CN-100457759-C | Cefepime halogen acid salt preparation method | SHENZHEN SALUBRIS PHARMACEUTIC (CN) | 2009-02-04 | — | — | CN | disclosed |
| CN-101104621-A | Technique for preparing high-purity cefpirome sulfate | SHENZHEN SALUBRIS PHARMACEUTIC (CN) | 2008-01-16 | — | — | CN | disclosed |
| CN-101045734-A | Preparation of cefepime hydrochlorice by sodium salt precipitation method | XINLITAI PHARMACEUTICAL CO LTD (CN) | 2007-10-03 | — | — | CN | disclosed |
| CN-101041664-A | Preparation of cefepime halogen acid salt by calcium salt precipitation process | SHENZHEN SALUBRIS PHARMACEUTIC (CN) | 2007-09-26 | — | — | CN | disclosed |
| CN-101007813-A | Cefepime halogen acid salt preparation method | SHENZHEN SALUBRIS PHARMACEUTIC (CN) | 2007-08-01 | — | — | CN | disclosed |
| EP-0920252-A4 | SILVER-BASED ANTIMICROBIAL COMPOSITIONS | CAPELLI CHRISTOPHER C (US) | 2004-08-18 | — | — | EP | disclosed |
| EP-0920252-A1 | SILVER-BASED ANTIMICROBIAL COMPOSITIONS | CAPELLI, Christopher C. (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006260-A1 | SILVER-BASED ANTIMICROBIAL COMPOSITIONS | CAPELLI CHRISTOPHER C (US) | 1998-02-19 | — | — | WO | disclosed |
| US-4948800-A | MUSCLE RELAXANTS; ANTICONVULSANTS; ANXIOLYTIC AGENTS; 3-HYDROXYALKYL-PYRIDO(4,5-B OR-C)IMIDAZOLE COMPOUNDS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-14 | — | — | US | disclosed |
| US-4914109-A | ANTICONVULSANTS, ANTIANXIETY AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-04-03 | — | — | US | disclosed |
| US-4873251-A | MUSCLE RELAXANTS, ANTICONVULSANTS, ANTIANXIETY AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-10-10 | — | — | US | disclosed |
| US-4824951-A | MUSCLE RELAXANTS, ANTICONVULSANTS, ANXIOLYTIC AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-04-25 | — | — | US | disclosed |
| US-4772600-A | MUSCLE RELAXANTS, ANTICONVULSANTS, ANXIOLYTIC | A. H. ROBINS COMPANY, INC. (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0255217-A1 | Fused imidazoheterocyclic compounds | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1988-02-03 | — | — | EP | disclosed |