Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062128 | 0.86 | KDM4E (0.83) | KDM4EALDH1A1MAPK1POLBMAPT | |
| SCHEMBL7051943 | 0.82 | KDM4E (0.72) | KDM4EALDH1A1MAPK1POLBMAPT | |
| SCHEMBL5849667 | 0.81 | KDM4E (0.71) | KDM4EALDH1A1MAPK1POLBMAPT | |
| SCHEMBL5851429 | 0.81 | KDM4E (0.74) | KDM4EALDH1A1MAPK1POLBMAPT | |
| SCHEMBL5848988 | 0.80 | ALDH1A1 (0.74) | KDM4EALDH1A1MAPK1POLBMAPT | |
| SCHEMBL14825132 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1MAPK1POLBMAPT | |
| SCHEMBL5851284 | 0.74 | MEN1 (0.73) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL12789875 | 0.73 | MEN1 (1.00) | KDM4EALDH1A1MAPK1POLBMAPT | |
| SCHEMBL5849263 | 0.73 | MEN1 (0.74) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL17775394 | 0.72 | MEN1 (0.71) | KDM4EALDH1A1MAPK1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |