Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053935 | 0.95 | KDM4E (0.47) | ALDH1A1L3MBTL1HIF1ANUDT1AXL | |
| SCHEMBL1978099 | 0.82 | HIF1A (0.44) | ALDH1A1HIF1ANUDT1AXLFLT3 | |
| SCHEMBL14497424 | 0.80 | IDO1 (0.40) | ALDH1A1L3MBTL1CASP6KDM4ELMNA | |
| SCHEMBL9639509 | 0.77 | GRM5 (0.49) | ALDH1A1HIF1ANUDT1AXLFLT3 | |
| SCHEMBL31420488 | 0.76 | KDM4E (0.46) | ALDH1A1HIF1ANUDT1AXLFLT3 | |
| SCHEMBL26686723 | 0.76 | KDM4E (0.46) | ALDH1A1HIF1ANUDT1AXLFLT3 | |
| SCHEMBL6657973 | 0.74 | LMNA (0.68) | ALDH1A1L3MBTL1LMNAKMT2AMAPT | |
| SCHEMBL1268978 | 0.72 | ALDH1A1 (0.65) | ALDH1A1HIF1ANUDT1AXLFLT3 | |
| SCHEMBL7609372 | 0.72 | DRD2 (0.53) | ALDH1A1KDM4ELMNAKMT2AMAPT | |
| SCHEMBL11454782 | 0.71 | EGFR (0.54) | L3MBTL1HIF1ACASP6KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307443-A2 | NOVEL SUBSTITUTED DIARYL AZEPINE DERIVATIVES AS INTEGRIN LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002014320-A2 | NOVEL SUBSTITUTED DIARYL AZEPINE DERIVATIVES AS INTEGRIN LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-21 | — | — | WO | disclosed |