Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 9/20 | 0.38 |
| ▸ | THRB | P10828 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054764 | 0.91 | NR3C1 (0.61) | NR3C1TRPV1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL7254981 | 0.85 | NR3C1 (0.57) | NR3C1THRATHRB | |
| SCHEMBL7051598 | 0.84 | NR3C1 (0.53) | NR3C1THRATHRB | |
| SCHEMBL7051600 | 0.82 | NR3C1 (0.53) | NR3C1THRATHRB | |
| SCHEMBL7252423 | 0.81 | NR3C1 (0.52) | NR3C1ALDH1A1THRATHRBMEN1 | |
| SCHEMBL7251618 | 0.80 | NR3C1 (0.52) | NR3C1THRATHRB | |
| SCHEMBL7256183 | 0.80 | NR3C1 (0.69) | NR3C1THRATHRB | |
| SCHEMBL7053515 | 0.80 | NR3C1 (0.72) | NR3C1THRATHRBKMT2A | |
| SCHEMBL7681978 | 0.79 | NR3C1 (0.71) | NR3C1CYP3A4CYP2C9THRATHRB | |
| SCHEMBL7053915 | 0.79 | NR3C1 (0.61) | NR3C1THRATHRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |