SCHEMBL7052450

SCHEMBL7052450

COc1ccc(C2CCCC(=O)C2)cc1OC

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 16/20 0.71
PDE4B Q07343 10/20 0.71
PDE4C Q08493 10/20 0.71
PDE4D Q08499 10/20 0.71
CYP3A4 P08684 2/20 0.50
VEGFA P15692 1/20 0.50
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
CYP1A2 P05177 1/20 0.50
MAPT P10636 1/20 0.50
CYP2C9 P11712 1/20 0.50
ALOX15 P16050 1/20 0.50
CREBBP Q92793 1/20 0.50
KDM4E B2RXH2 1/20 0.50
PDE5A O76074 1/20 0.50
TNF P01375 1/20 0.50
MAPK1 P28482 1/20 0.50
BLM P54132 1/20 0.50
PDE1A P54750 1/20 0.50
PDE1B Q01064 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL426375 0.85 PDE4A (0.64) PDE4APDE4BPDE4CPDE4DVEGFA
SCHEMBL7362034 0.83 PDE4B (1.00) PDE4APDE4BPDE4CPDE4DCYP3A4
SCHEMBL13588637 0.83 PDE4B (1.00) PDE4APDE4BPDE4CPDE4DCYP3A4
SCHEMBL13588642 0.83 PDE4B (1.00) PDE4APDE4BPDE4CPDE4DCYP3A4
SCHEMBL25279761 0.83 PDE4A (0.55) PDE4APDE4BPDE4CPDE4DCYP3A4
SCHEMBL25285478 0.82 PDE4A (0.54) PDE4APDE4BPDE4CPDE4DCYP3A4
SCHEMBL7054809 0.82 PDE4A (0.60) PDE4APDE4BPDE4CPDE4DMAPT
SCHEMBL3536936 0.82 PDE4A (0.76) PDE4APDE4BPDE4CPDE4DCYP3A4
SCHEMBL9188312 0.81 NR3C1 (0.60) PDE4APDE4BPDE4CPDE4DNR3C1
SCHEMBL19010044 0.81 ALDH1A1 (0.51) PDE4APDE4BPDE4CPDE4DALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0940387-B1 PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME MITSUBISHI PHARMA CORP (JP) 2003-05-07 EP disclosed
US-6069176-A PHENYLETHANOLAMINE COMPOUNDS WITH A BETA-3 ADRENERGIC RECEPTOR STIMULATING EFFECT, USE AS A THERAPY FOR URINARY INCONTINENCE MITSUBISHI-TOKYO PHARMACEUTICALS, INC. (JP) 2000-05-30 US disclosed
EP-0940387-A1 PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME TOKYO TANABE COMPANY LIMITED (JP) 1999-09-08 EP disclosed