Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9271719 | 0.93 | KDM4E (0.53) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL11866119 | 0.81 | MAPT (0.54) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL30009774 | 0.80 | POLB (0.56) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL11830142 | 0.80 | KDM4E (0.48) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL11830152 | 0.78 | KDM4E (0.49) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL18312147 | 0.77 | POLB (0.57) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL9109729 | 0.77 | POLB (0.53) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL9109725 | 0.77 | POLB (0.53) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL23645504 | 0.77 | POLB (0.53) | KDM4EPOLBPTPN1MAPTALDH1A1 | |
| SCHEMBL276154 | 0.74 | MAOB (0.48) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608215-B2 | Photochromic ophthalmic or sun protection lenses, glass paneling | VISION-EASE LENS, INC. | 2003-08-19 | — | — | US | disclosed |
| US-20030092918-A1 | Oxygen-containing heterocyclic fused naphthopyrans | VISION-EASE LENS, INC. | 2003-05-15 | — | — | US | disclosed |
| WO-2003025638-A1 | OXYGEN-CONTAINING HETEROCYCLIC FUSED NAPHTHOPYRANS | VISION-EASE LENS, INC. (US) | 2003-03-27 | — | — | WO | disclosed |
| EP-0946536-B1 | (BENZOFURAN)NAPHTHOPYRANS, THE COMPOSITIONS AND (CO)POLYMER MATRICES CONTAINING THEM | CORNING INC (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-0946536-A4 | (BENZOFURAN)NAPHTHOPYRANS, THE COMPOSITIONS AND (CO)POLYMER MATRICES CONTAINING THEM | CORNING INC (US) | 2000-03-08 | — | — | EP | disclosed |
| US-6018059-A | INTERESTING PHOTOCHROMIC PROPERTIES; CAN BE CROSSLINKED OR POLYMERIZED WHEN FUNCTIONALIZED WITH EPOXY, ALKENYL, OR (METH)ACRYLOYL GROUPS; OPHTHALMIC DEVICES, GLAZINGS, OR SOLAR ARTICLES | CORNING INCORPORATED (US) | 2000-01-25 | — | — | US | disclosed |
| EP-0946536-A1 | (BENZOFURAN)NAPHTHOPYRANS, THE COMPOSITIONS AND (CO)POLYMER MATRICES CONTAINING THEM | CORNING INCORPORATED (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028289-A1 | (BENZOFURAN)NAPHTHOPYRANS, THE COMPOSITIONS AND (CO)POLYMER MATRICES CONTAINING THEM | CORNING INCORPORATED (US) | 1998-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092918-A1 | Oxygen-containing heterocyclic fused naphthopyrans | NQO1, NFE2L2, NDUFV2 | KDM4E 2524/4885POLB 2071/4885PTPN1 2665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.