Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 7/20 | 0.34 |
| ▸ | THRA | P10827 | 5/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053492 | 0.90 | NR3C1 (0.58) | NR3C1CYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL7054486 | 0.89 | NR3C1 (0.82) | NR3C1THRBTHRA | |
| SCHEMBL7688423 | 0.88 | NR3C1 (0.69) | NR3C1CYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL7054470 | 0.80 | NR3C1 (0.84) | NR3C1CYP1A2CYP3A4CYP2C19THRB | |
| SCHEMBL7052325 | 0.79 | NR3C1 (0.84) | NR3C1CYP1A2CYP2C19HPGDTHRB | |
| SCHEMBL7054567 | 0.79 | NR3C1 (0.83) | NR3C1THRBTHRA | |
| SCHEMBL5632584 | 0.79 | NR3C1 (1.00) | NR3C1THRBTHRA | |
| SCHEMBL7681978 | 0.79 | NR3C1 (0.71) | NR3C1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL7051707 | 0.79 | NR3C1 (0.74) | NR3C1MAPTTHRBTHRA | |
| SCHEMBL5630623 | 0.78 | NR3C1 (0.85) | NR3C1CYP1A2CYP3A4CYP2C19LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |