Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PAX3 | P23760 | 1/20 | 0.33 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053284 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL7782815 | 0.79 | KDM4E (0.41) | SMN1; SMN2LMNATSHRKDM4EPAX3 | |
| SCHEMBL7782820 | 0.79 | KDM4E (0.41) | SMN1; SMN2LMNATSHRKDM4EPAX3 | |
| SCHEMBL12714672 | 0.79 | TYMP (0.59) | TYMPPOLBKDM4E | |
| SCHEMBL3821714 | 0.79 | TYMP (0.59) | TYMPPOLBKDM4E | |
| SCHEMBL21828784 | 0.79 | TYMP (0.59) | TYMPPOLBKDM4E | |
| SCHEMBL2281663 | 0.79 | TYMP (0.59) | TYMPPOLBKDM4E | |
| SCHEMBL31556051 | 0.79 | TYMP (0.59) | TYMPPOLBKDM4E | |
| SCHEMBL30274928 | 0.78 | TYMP (0.44) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL27041210 | 0.78 | TYMP (0.44) | SMN1; SMN2NPC1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301523-A1 | N8 - AND C8 -LINKED PURINE BASES AND STRUCTURALLY RELATED HETEROCYCLES AS UNIVERSAL NUCLEOSIDES USED FOR OLIGONUCLEOTIDE HYBRIDIZATION | Roche Diagnostics GmbH (DE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2001072764-A1 | N?8- AND C8¿-LINKED PURINE BASES AND STRUCTURALLY RELATED HETEROCYCLES AS UNIVERSAL NUCLEOSIDES USED FOR OLIGONUCLEOTIDE HYBRIDIZATION | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | WO | disclosed |
| EP-1138689-A1 | N8- and C8-linked purine bases as universal nucleosides used for oligonucleotide hybridization | Roche Diagnostics GmbH (DE) | 2001-10-04 | — | — | EP | disclosed |
| EP-1138688-A1 | N8- and C8- linked purine bases as universal nucleosides used for oligonucleotide hybridization | Roche Diagnostics GmbH (DE) | 2001-10-04 | — | — | EP | disclosed |