Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 10/20 | 0.39 |
| ▸ | THRA | P10827 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7249278 | 0.86 | NR3C1 (0.62) | NR3C1THRBTHRA | |
| SCHEMBL7050839 | 0.83 | NR3C1 (0.48) | NR3C1THRBTHRAKMT2AMEN1 | |
| SCHEMBL7250252 | 0.81 | NR3C1 (0.58) | NR3C1THRBTHRA | |
| SCHEMBL7250267 | 0.80 | NR3C1 (0.61) | NR3C1THRBTHRA | |
| SCHEMBL7250117 | 0.78 | NR3C1 (0.62) | NR3C1THRBTHRA | |
| SCHEMBL7249537 | 0.78 | NR3C1 (0.70) | NR3C1THRBTHRA | |
| SCHEMBL7052041 | 0.77 | NR3C1 (0.37) | NR3C1THRBTHRAKMT2AMEN1 | |
| SCHEMBL7251617 | 0.77 | NR3C1 (0.59) | NR3C1THRBTHRA | |
| SCHEMBL7250218 | 0.77 | NR3C1 (0.59) | NR3C1THRBTHRA | |
| SCHEMBL7549525 | 0.77 | NR3C1 (0.63) | NR3C1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |