Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.37 |
| ▸ | TUBB | P07437 | 6/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050494 | 0.85 | NR3C1 (0.70) | NR3C1 | |
| SCHEMBL7051558 | 0.84 | NR3C1 (0.59) | NR3C1 | |
| SCHEMBL7048724 | 0.78 | NR3C1 (0.65) | NR3C1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL7052045 | 0.76 | NR3C1 (0.78) | NR3C1SMN1; SMN2LMNA | |
| SCHEMBL7050581 | 0.76 | NR3C1 (0.63) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7055432 | 0.76 | NR3C1 (0.73) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7054015 | 0.75 | NR3C1 (0.66) | NR3C1SMN1; SMN2LMNA | |
| SCHEMBL7052325 | 0.74 | NR3C1 (0.84) | NR3C1CYP1A2CYP2C19 | |
| SCHEMBL7054883 | 0.73 | NR3C1 (0.60) | NR3C1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7052439 | 0.73 | NR3C1 (0.75) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | claimed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | claimed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | claimed |
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |