Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.53 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7055491 | 0.99 | LTA4H (0.57) | LTA4HTSHRKDM4EPOLBALDH1A1 | |
| SCHEMBL28387724 | 0.87 | TSHR (0.56) | LTA4HTSHRKDM4EPOLBALDH1A1 | |
| SCHEMBL29944824 | 0.87 | ALDH1A1 (0.71) | TSHRKDM4EPOLBALDH1A1MAPT | |
| SCHEMBL3837994 | 0.87 | LTA4H (0.55) | LTA4HTSHRKDM4EPOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL25311845 | 0.86 | ALDH1A1 (0.69) | TSHRKDM4EPOLBALDH1A1MAPT | |
| SCHEMBL2741669 | 0.84 | LTA4H (0.58) | LTA4HKDM4EALDH1A1HTTPSMB1 | |
| SCHEMBL2741670 | 0.84 | LTA4H (0.58) | LTA4HKDM4EALDH1A1HTTPSMB1 | |
| Hydrochloric Acid SCHEMBL227145 | 0.83 | LTA4H (0.57) | LTA4HKDM4EALDH1A1HTTPSMB1 | |
| Hydrochloric Acid SCHEMBL228984 | 0.83 | LTA4H (0.57) | LTA4HKDM4EALDH1A1HTTPSMB1 | |
| SCHEMBL337560 | 0.81 | MRGPRX4 (0.58) | TSHRPOLBMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791590-B1 | Benzothiophenes, and formulations and methods using same | LILLY CO ELI (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6432982-B1 | TREATING POST-MENOPAUSAL WOMEN HAVING OSTEOPOROSIS, CARDIOVASCULAR DISORDERS AND ESTROGEN-DEPENDENT CANCER; RESTENOSIS INHIBITION; ENDOMETRIOSIS | ELI LILLY AND COMPANY | 2002-08-13 | — | — | US | disclosed |
| EP-0791590-A1 | Benzothiophenes, and formulations and methods using same | ELI LILLY AND COMPANY (US) | 1997-08-27 | — | — | EP | disclosed |