SCHEMBL7053846

SCHEMBL7053846

Cc1cccc(C)c1N=CCc1cccc(CC=Nc2c(C)cccc2C)n1

nearest known ligand 0.33

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.33
KCNH2 Q12809 2/20 0.32
HRH4 Q9H3N8 1/20 0.32
MEN1 O00255 1/20 0.32
HSP90AA1 P07900 1/20 0.32
KMT2A Q03164 1/20 0.32
ATM Q13315 1/20 0.32
NOS1 P29475 1/20 0.32
NOS2 P35228 1/20 0.32
GRIN2D O15399 1/20 0.32
GRIN3B O60391 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32
GRIN2B Q13224 1/20 0.32
GRIN2C Q14957 1/20 0.32
GRIN3A Q8TCU5 1/20 0.32
NPSR1 Q6W5P4 1/20 0.31
CXCR4 P61073 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL16654018 0.96 POLB (0.31) POLBKCNH2HRH4MEN1HSP90AA1
SCHEMBL18543986 0.91 BACE1 (0.33) KCNH2MEN1HSP90AA1KMT2AATM
SCHEMBL4969524 0.91 BACE1 (0.35)
SCHEMBL812525 0.88 NOS1 (0.39) KCNH2HRH4MEN1HSP90AA1KMT2A
SCHEMBL18543890 0.88 TSHR (0.35)
Hydrochloric Acid SCHEMBL39685 0.86 BACE1 (0.34)
Hydrochloric Acid SCHEMBL811296 0.85 NOS1 (0.37) MEN1KMT2ANOS1NOS2NPSR1
SCHEMBL4968889 0.84 NQO2 (0.31) MEN1HSP90AA1KMT2AATM
SCHEMBL4967907 0.84 NOS1 (0.33) MEN1HSP90AA1KMT2AATMNOS1
SCHEMBL4968015 0.84 ALDH1A1 (0.33) MEN1HSP90AA1KMT2AATMNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3135697-B1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF CHINA PETROLEUM & CHEM CORP (CN) 2019-08-14 EP claimed
WO-2003020778-A1 MULTI-DENTATE LATE TRANSITION METAL CATALYST COMPLEXES AND POLYMERIZATION METHODS USING THOSE COMPLEXES EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2003-03-13 WO disclosed