SCHEMBL4968015

SCHEMBL4968015

Cc1cccc(C)c1N=CCc1cccc(CC=Nc2c(C)cc(Cl)cc2Cl)n1

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
CRHR1 P34998 2/20 0.31
MEN1 O00255 1/20 0.30
HSP90AA1 P07900 1/20 0.30
KMT2A Q03164 1/20 0.30
ATM Q13315 1/20 0.30
BACE1 P56817 2/20 0.30
MRGPRX4 Q96LA9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4970674 0.94 RAPGEF4 (0.34) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL39584 0.93 KDM4E (0.35) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL4969524 0.88 BACE1 (0.35) BACE1
SCHEMBL23535362 0.86 NOS1 (0.34) BACE1
SCHEMBL16653951 0.85 NOS1 (0.35) BACE1
SCHEMBL7053846 0.84 POLB (0.33) NPSR1MEN1HSP90AA1KMT2AATM
SCHEMBL14830125 0.84 NOS1 (0.34) BACE1
Hydrochloric Acid SCHEMBL39685 0.83 BACE1 (0.34) BACE1
Hydrochloric Acid SCHEMBL3671010 0.83 NOS1 (0.33) BACE1
SCHEMBL20703459 0.82 NOS1 (0.35) BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1973879-A2 PROCESS FOR PREPARING IMINO COMPOUNDS Basell Polyolefine GmbH (DE) 2008-10-01 EP disclosed
WO-2007080121-A2 PROCESS FOR PREPARING IMINO COMPOUNDS BASELL POLYOLEFINE GMBH (DE) 2007-07-19 WO disclosed