Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.35 |
| ▸ | SIK1 | P57059 | 1/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056667 | 0.81 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7056722 | 0.79 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7364178 | 0.77 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7055267 | 0.76 | LMNA (0.40) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7362735 | 0.76 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7051026 | 0.75 | POLB (0.42) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7054012 | 0.75 | IKBKB (0.39) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7053044 | 0.75 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7052278 | 0.74 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7053150 | 0.73 | AAK1 (0.40) | PDE4APDE4BPDE4CPDE4DMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |