Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 4/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364178 | 0.95 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DADRB2 | |
| SCHEMBL7052278 | 0.81 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7053973 | 0.81 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7057558 | 0.80 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7051176 | 0.79 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7056722 | 0.78 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7055258 | 0.78 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7048142 | 0.76 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DSLC9A1 | |
| SCHEMBL7053044 | 0.76 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7052699 | 0.75 | IKBKB (0.45) | PDE4APDE4BPDE4CPDE4DSLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |