Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.35 |
| ▸ | TDP2 | O95551 | 3/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056722 | 0.96 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7056892 | 0.81 | LMNA (0.40) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7054012 | 0.80 | IKBKB (0.39) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7055258 | 0.80 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| O-Tolylamine SCHEMBL7366469 | 0.78 | IKBKB (0.38) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7048142 | 0.77 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7053044 | 0.76 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7052699 | 0.76 | IKBKB (0.45) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7053973 | 0.76 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DMKNK2 | |
| SCHEMBL7053150 | 0.75 | AAK1 (0.40) | PDE4APDE4BPDE4CPDE4DMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |