Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 12/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047712 | 0.82 | HTT (0.39) | HTTSMN1; SMN2TSHRTP53MAPT | |
| SCHEMBL7051711 | 0.82 | HTT (0.39) | HTTSMN1; SMN2TSHRTP53MAPT | |
| SCHEMBL7049255 | 0.81 | P2RY12 (0.39) | HTTSMN1; SMN2TSHRTP53MAPT | |
| SCHEMBL7053983 | 0.81 | HTR6 (0.47) | HTTSMN1; SMN2TSHRTP53MAPT | |
| SCHEMBL7052952 | 0.81 | ALDH1A1 (0.40) | HTTSMN1; SMN2TSHRMAPTNPSR1 | |
| SCHEMBL7049314 | 0.81 | HTT (0.39) | HTTSMN1; SMN2TSHRTP53MAPT | |
| SCHEMBL7050548 | 0.81 | P2RY12 (0.39) | HTTSMN1; SMN2TSHRTP53MAPT | |
| SCHEMBL7051550 | 0.81 | P2RY12 (0.39) | HTTSMN1; SMN2TSHRTP53MAPT | |
| SCHEMBL7049301 | 0.80 | HTT (0.38) | HTTSMN1; SMN2TSHRTP53MAPT | |
| SCHEMBL7052685 | 0.80 | SMN1; SMN2 (0.53) | HTTSMN1; SMN2TSHRTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |