SCHEMBL7054633

SCHEMBL7054633

CC1=Cc2c(-c3ccccc3)cccc2C1c1cccc([SiH2]Cl)c1C

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
CHRNB2 P17787 1/20 0.31
CHRNA4 P43681 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22418862 0.79 CHRNB2 (0.36) PDCD1CD274CHRNB2CHRNA4
SCHEMBL5080424 0.74 ALDH1A1 (0.33) PDCD1CD274CHRNB2CHRNA4
SCHEMBL7055187 0.74 CHRNB2 (0.33) PDCD1CD274CHRNB2CHRNA4
SCHEMBL28550963 0.72 PDCD1 (0.36) PDCD1CD274CHRNB2CHRNA4
SCHEMBL28502203 0.72 CD274 (0.39) PDCD1CD274CHRNB2CHRNA4
SCHEMBL28503065 0.72 PDCD1 (0.39) PDCD1CD274CHRNB2CHRNA4
SCHEMBL27384613 0.71 PDCD1 (0.35) PDCD1CD274CHRNB2CHRNA4
SCHEMBL5694274 0.70 PDCD1 (0.37) PDCD1CD274CHRNB2CHRNA4
SCHEMBL7048688 0.70 PDCD1 (0.34) PDCD1CD274CHRNB2CHRNA4
Chloromethane SCHEMBL5722647 0.70 PDCD1 (0.34) PDCD1CD274CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985674-B1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR ALPHA-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING ALPHA-OLEFIN POLYMERS MITSUBISHI CHEM CORP (JP) 2003-04-23 EP disclosed
US-6255515-B1 COORDINATION POLYMERIZATION CATALYSTS MITSUBISHI CHEMICAL CORPORATION (JP) 2001-07-03 US disclosed
EP-0985674-A1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS MITSUBISHI CHEMICAL CORPORATION (JP) 2000-03-15 EP disclosed