Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051464 | 0.89 | PDE4D (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6959410 | 0.79 | PDE4D (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6950936 | 0.78 | PDE4D (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13741889 | 0.75 | PDE4D (0.83) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7048881 | 0.75 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5722927 | 0.75 | PDE4D (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7916544 | 0.74 | PDE4D (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7052318 | 0.74 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL11752418 | 0.73 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7053201 | 0.73 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |