Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17123632 | 0.86 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL1644965 | 0.86 | MAPK1 (0.59) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL6970823 | 0.85 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL3150784 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL30168125 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL1404979 | 0.83 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL7236261 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL19924420 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL15591161 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL6475322 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1304325-A1 | 5-(M-CYANOBENZYLAMINO)PYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-04-23 | — | — | EP | disclosed |
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| CN-1284075-A | Novel compounds having CGMP-PDE inhibitory effect | MOCHIDA PHARM CO LTD (JP) | 2001-02-14 | — | — | CN | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |