Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 14/20 | 0.73 |
| ▸ | DRD2 | P14416 | 11/20 | 0.73 |
| ▸ | DRD4 | P21917 | 2/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7058039 | 0.89 | DRD3 (0.79) | DRD3DRD2DRD4KCNH2ADRA1A | |
| SCHEMBL7052223 | 0.85 | DRD3 (0.77) | DRD3DRD2DRD4ADRA1AUSP2 | |
| SCHEMBL24805478 | 0.85 | DRD3 (1.00) | DRD3DRD2DRD4 | |
| SCHEMBL7052681 | 0.84 | DRD3 (0.67) | DRD3DRD2DRD4ADRA1A | |
| SCHEMBL7056313 | 0.82 | DRD3 (0.73) | DRD3DRD2DRD4KCNH2ADRA1A | |
| SCHEMBL7057318 | 0.81 | CCR3 (0.54) | DRD3DRD2DRD4ALDH1A1 | |
| SCHEMBL7056439 | 0.80 | DRD2 (0.76) | DRD3DRD2DRD4ADRA1A | |
| SCHEMBL12946337 | 0.80 | DRD3 (0.61) | DRD3DRD2DRD4KCNH2ADRA1A | |
| SCHEMBL4536353 | 0.79 | DRD3 (1.00) | DRD3DRD2DRD4KCNH2ADRA1A | |
| SCHEMBL7050873 | 0.78 | DRD2 (0.67) | DRD3DRD2DRD4KCNH2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |