Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 12/20 | 0.77 |
| ▸ | DRD2 | P14416 | 11/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055846 | 0.85 | DRD3 (0.73) | DRD3DRD2ADRA1ADRD4MAPT | |
| SCHEMBL7056439 | 0.83 | DRD2 (0.76) | DRD3DRD2ADRA1ADRD4 | |
| SCHEMBL31061220 | 0.81 | DRD3 (0.84) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL7057592 | 0.81 | OPRK1 (0.57) | DRD3DRD2DRD4ALDH1A1 | |
| SCHEMBL4525601 | 0.80 | HSD17B10 (0.72) | DRD3DRD2ADRA1ADRD4HTR1A | |
| SCHEMBL3205704 | 0.78 | HTR7 (0.62) | DRD3DRD2HTR7HTR1AHTR2A | |
| SCHEMBL4521840 | 0.78 | DRD4 (0.77) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL7369877 | 0.77 | DRD3 (0.77) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL14006003 | 0.77 | TSHR (0.70) | DRD3DRD2DRD4MAPTALDH1A1 | |
| SCHEMBL3205692 | 0.77 | HTR7 (0.63) | DRD3DRD2HTR7HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |