SCHEMBL7056623

SCHEMBL7056623

COc1cccc(SC)c1C=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.45
ERN1 O75460 4/20 0.44
TLR2 O60603 1/20 0.44
TLR1 Q15399 1/20 0.44
TLR6 Q9Y2C9 1/20 0.44
TSHR P16473 2/20 0.43
ALDH1A1 P00352 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HSD17B10 Q99714 1/20 0.42
ABCG2 Q9UNQ0 1/20 0.41
ABCB1 P08183 1/20 0.40
NFE2L2 Q16236 2/20 0.40
TFEB P19484 1/20 0.40
PRKDC P78527 1/20 0.39
CYP1A1 P04798 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP1B1 Q16678 1/20 0.39
GAA P10253 1/20 0.38
HTT P42858 1/20 0.38
SRC P12931 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL170690 0.82 ERN1 (0.55) ERN1TLR2TLR1TLR6TSHR
SCHEMBL16494533 0.80 ALDH1A1 (0.43) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL27685686 0.78 ERN1 (0.52) ERN1TLR2TLR1TLR6TSHR
Bromomethane SCHEMBL28079811 0.78 ERN1 (0.52) ERN1TLR2TLR1TLR6TSHR
SCHEMBL11172018 0.76 KMT2A (0.38) POLBALDH1A1SMN1; SMN2GAAHTT
SCHEMBL4438690 0.76 ERN1 (0.44) POLBERN1TLR2TLR1TLR6
SCHEMBL3397850 0.76 RAB9A (0.46) POLBALDH1A1SMN1; SMN2GAAHTT
SCHEMBL27153905 0.76 MAPT (0.54) ERN1SMN1; SMN2GAA
SCHEMBL953118 0.75 ERN1 (0.48) ERN1TLR2TLR1TLR6TSHR
SCHEMBL1028678 0.75 ERN1 (0.63) ERN1TLR2TLR1TLR6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6566307-B1 For use as herbicides BASF AKTIENGESELLSCHAFT (DE) 2003-05-20 US disclosed
EP-1194408-B1 $g(A)-$g(a)'-SUBSTITUTED N-ALKYL-3-ALKENYLBENZOYL-PYRAZOL-DERIVATIVES BASF AG (DE) 2003-05-02 EP disclosed
US-6475957-B1 N-cycloalkyl-3-alkenybenzoyl-pyrazole derivatives BASF AKTIENGESELLSCHAFT (DE) 2002-11-05 US disclosed
EP-1194407-A2 N-CYCLOALKYL-3-ALKENYLBENZOYL-PYRAZOLE DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 2002-04-10 EP disclosed
EP-1194408-A2 $g(A)-$g(a)'-SUBSTITUTED N-ALKYL-3-ALKENYLBENZOYL-PYRAZOL-DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 2002-04-10 EP disclosed
WO-2001004096-A2 N-CYCLOALKYL-3-ALKENYLBENZOYL-PYRAZOLE DERIVATIVES AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2001-01-18 WO disclosed
WO-2001004095-A2 Α-α'-SUBSTITUTED N-ALKYL-3-ALKENYLBENZOYL-PYRAZOL-DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 2001-01-18 WO disclosed