SCHEMBL27685686

SCHEMBL27685686

COc1cccc(OC)c1C=O.[Na+].[PH2-]

nearest known ligand 0.52

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 known ✓ O43570 2/20 0.46
CA1 known ✓ P00915 2/20 0.46
CA2 known ✓ P00918 2/20 0.46
CA4 known ✓ P22748 1/20 0.46
ERN1 O75460 4/20 0.52
TLR2 O60603 1/20 0.52
TLR1 Q15399 1/20 0.52
TLR6 Q9Y2C9 1/20 0.52
ALDH1A1 P00352 3/20 0.47
ABCG2 Q9UNQ0 1/20 0.47
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
CYP1A1 P04798 2/20 0.44
CYP1A2 P05177 2/20 0.44
CYP1B1 Q16678 2/20 0.44
SRC P12931 1/20 0.43
AMY1A P0DUB6 1/20 0.43
TSHR P16473 1/20 0.42
NFE2L2 Q16236 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL170690 0.95 ERN1 (0.55) ERN1TLR2TLR1TLR6ALDH1A1
Bromomethane SCHEMBL28079811 0.91 ERN1 (0.52) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL1028678 0.83 ERN1 (0.63) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL953118 0.83 ERN1 (0.48) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL4541926 0.82 CYP1A2 (0.54) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL9956453 0.82 ERN1 (0.44) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL747870 0.82 TLR2 (0.44) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL459037 0.81 ALDH1A1 (0.61) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL15945775 0.81 ERN1 (0.47) ERN1TLR2TLR1TLR6ALDH1A1
SCHEMBL743608 0.81 ALDH1A1 (0.57) ERN1TLR2TLR1TLR6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102405239-B polymer nanoparticles EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH (CH) 2014-10-15 CN disclosed
CN-102405239-A Polymer nanoparticles ETH ZUERICH 2012-04-04 CN disclosed
CN-101065388-B Process for preparing acylphosphanes and derivatives thereof CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2011-12-21 CN disclosed
CN-101065388-A Process for preparing acylphosphanes and derivatives thereof CIBA SC HOLDING AG (CH) 2007-10-31 CN disclosed