Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 7/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364777 | 0.87 | APP (0.75) | APPCA12CA1CA2CA9 | |
| SCHEMBL28886 | 0.84 | APP (0.35) | APPCA12CA1CA2CA9 | |
| SCHEMBL3080258 | 0.82 | APP (0.67) | APPCA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL9124177 | 0.82 | CYP3A4 (0.33) | APPCA12CA1CA2CA9 | |
| SCHEMBL7054237 | 0.80 | CA12 (0.54) | CA12CA1CA2CA9PTPN11 | |
| SCHEMBL1070719 | 0.79 | MAPT (0.35) | APPCA12CA1CA2CA9 | |
| SCHEMBL2450399 | 0.79 | APP (0.80) | APPCA12CA1CA2CA9 | |
| Diphenylacetylene SCHEMBL27819130 | 0.79 | APP (0.80) | APPCA12CA1CA2CA9 | |
| Diphenylacetylene SCHEMBL27628902 | 0.79 | APP (0.92) | APPCA12CA1CA2CA9 | |
| SCHEMBL97617 | 0.76 | MGLL (0.45) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |