Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.47 |
| ▸ | THRA | P10827 | 8/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7058208 | 0.91 | THRB (0.44) | THRBTHRACYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7025989 | 0.85 | THRA (0.49) | THRBTHRAMEN1KMT2A | |
| SCHEMBL7029599 | 0.76 | THRB (0.51) | THRBTHRA | |
| SCHEMBL8801787 | 0.71 | THRB (0.58) | THRBTHRA | |
| SCHEMBL6622195 | 0.70 | THRB (0.69) | THRBTHRA | |
| SCHEMBL7058944 | 0.69 | HPGD (0.43) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL5393859 | 0.67 | THRB (0.66) | THRBTHRA | |
| SCHEMBL6622191 | 0.67 | THRB (0.69) | THRBTHRA | |
| SCHEMBL8799407 | 0.67 | THRA (0.56) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL23983024 | 0.65 | THRA (0.60) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307426-A1 | AMINO DIPHENYL ETHERS AND AMIDO DIPHENYL ETHERS | Bayer Aktiengesellschaft (DE) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012169-A1 | AMINO DIPHENYL ETHERS AND AMIDO DIPHENYL ETHERS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-02-14 | — | — | WO | disclosed |