Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 17/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 16/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8822708 | 0.75 | MTNR1B (0.35) | MTNR1BMTNR1AHTR2CAKR1C3 | |
| SCHEMBL7050429 | 0.72 | MTNR1A (0.53) | MTNR1BMTNR1AHTR2CAKR1C3 | |
| SCHEMBL7060018 | 0.71 | MTNR1A (0.42) | MTNR1BMTNR1AHTR2CAKR1C3 | |
| SCHEMBL8717303 | 0.69 | PLA2G2A (0.33) | AKR1C3 | |
| SCHEMBL7056903 | 0.68 | MTNR1B (0.41) | MTNR1BMTNR1AHTR2C | |
| SCHEMBL8712353 | 0.67 | PTGS1 (0.37) | MTNR1BMTNR1A | |
| SCHEMBL8715700 | 0.67 | PTGS1 (0.39) | — | |
| SCHEMBL8717299 | 0.67 | PTGS1 (0.35) | MTNR1BMTNR1AAKR1C3 | |
| SCHEMBL7055812 | 0.66 | MTNR1A (0.61) | MTNR1BMTNR1A | |
| SCHEMBL4967386 | 0.65 | MTNR1A (0.76) | MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656209-B1 | Melatonin derivatives for use in treating desynchronization disorders | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-0655243-B1 | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 2002-08-21 | — | — | EP | disclosed |
| US-6180657-B1 | SLEEP DISORDERS | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-5654325-A | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0748627-A2 | Melatonin agonists for use in the treatment of benign prostatic hyperplasia | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0656209-A2 | Melatonin derivatives for use in treating desynchronization disorders | ELI LILLY AND COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0655243-A2 | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4997845-A | β-alkylmelatonins as ovulation inhibitors | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |