Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.69 |
| ▸ | DRD3 | P35462 | 15/20 | 0.69 |
| ▸ | HTR1A | P08908 | 9/20 | 0.69 |
| ▸ | HTR2A | P28223 | 7/20 | 0.69 |
| ▸ | HTR2C | P28335 | 7/20 | 0.69 |
| ▸ | DRD4 | P21917 | 7/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.61 |
| ▸ | HTR2B | P41595 | 4/20 | 0.61 |
| ▸ | DRD1 | P21728 | 2/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521349 | 0.81 | DRD3 (0.73) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL7053717 | 0.80 | DRD3 (0.71) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL17194866 | 0.80 | DRD2 (1.00) | DRD2DRD3HTR1ADRD4KCNH2 | |
| SCHEMBL1543274 | 0.80 | DRD2 (0.65) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL7052933 | 0.79 | DRD2 (0.66) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL7056485 | 0.78 | DRD2 (0.64) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL4533987 | 0.78 | SLC6A4 (0.72) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL14006129 | 0.77 | DRD2 (0.69) | DRD2DRD3HTR1AHTR2AHTR2C | |
| Bp-897 SCHEMBL2125882 | 0.77 | DRD2 (1.00) | DRD2DRD3HTR1AHTR2AHTR2C | |
| Bp-897 SCHEMBL29382551 | 0.77 | DRD2 (1.00) | DRD2DRD3HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |