Acrylamide

Acrylamide

SCHEMBL7059174

C=CC(N)=O.CS(=O)(=O)[O-].[Na+]

nearest known ligand 0.58

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Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.58
TSHR P16473 3/20 0.58
FGFR4 P22455 1/20 0.58
TGM2 P21980 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
LMNA P02545 1/20 0.32
LDHA P00338 1/20 0.30
BLM P54132 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylamide SCHEMBL28217383 0.89 ALDH1A1 (0.65) ALDH1A1TSHRFGFR4MEN1KMT2A
Acrylamide SCHEMBL23607548 0.85 ALDH1A1 (0.52) ALDH1A1TSHRFGFR4MEN1KMT2A
Vinylsulfonic Acid SCHEMBL10963895 0.84 ALDH1A1 (0.58) ALDH1A1TSHRFGFR4MEN1KMT2A
Acrylamide SCHEMBL19272435 0.83 TSHR (0.65) ALDH1A1TSHRFGFR4TGM2LMNA
Acrylamide SCHEMBL29021215 0.83 ALDH1A1 (0.65) ALDH1A1TSHRFGFR4MEN1KMT2A
Acrylamide SCHEMBL28835521 0.83 ALDH1A1 (0.65) ALDH1A1TSHRFGFR4MEN1KMT2A
Acrylamide SCHEMBL14118871 0.83 ALDH1A1 (0.65) ALDH1A1TSHRFGFR4MEN1KMT2A
Acrylamide SCHEMBL432101 0.83 TSHR (0.65) ALDH1A1TSHRFGFR4TGM2LMNA
Acrylamide SCHEMBL14118868 0.83 ALDH1A1 (0.65) ALDH1A1TSHRFGFR4MEN1KMT2A
Acrylamide SCHEMBL27543640 0.83 TSHR (0.65) ALDH1A1TSHRFGFR4TGM2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3138940-A1 ACRYLIC FIBERS, METHOD FOR MANUFACTURING SAME, AND SPUN YARN AND KNITTED FABRIC USING SAID FIBERS Mitsubishi Rayon Co., Ltd. (JP) 2017-03-08 EP disclosed
US-20170044693-A1 ACRYLIC FIBERS, METHOD FOR MANUFACTURING SAME, AND SPUN YARN AND KNITTED FABRIC USING SAID FIBERS MITSUBISHI RAYON CO., LTD. (JP) 2017-02-16 US disclosed
EP-1021466-B1 POLYMERISATION PROCESSES AND PRODUCTS AND USES OF THE PRODUCTS CIBA SPEC CHEM WATER TREAT LTD (GB) 2003-05-07 EP disclosed
US-6407161-B1 Polymerization processes and products and uses of the products CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-18 US disclosed
EP-1021466-A1 POLYMERISATION PROCESSES AND PRODUCTS AND USES OF THE PRODUCTS Ciba Specialty Chemicals Water Treatments Limited (GB) 2000-07-26 EP disclosed
WO-1999014246-A1 POLYMERISATION PROCESSES AND PRODUCTS AND USES OF THE PRODUCTS CIBA SPECIALTY CHEMICALS WATER TREATMENTS LIMITED (GB) 1999-03-25 WO disclosed