Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 3/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 4/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518626 | 0.73 | HSD11B1 (0.38) | — | |
| SCHEMBL5662615 | 0.72 | LOXL2 (0.35) | KDM4EMAPTNOS2NOS3NOS1 | |
| SCHEMBL643420 | 0.72 | MAPT (0.38) | MAPTITGB3ITGAV | |
| SCHEMBL30912531 | 0.71 | HTR2C (0.45) | BACE1KDM4EMAPTXIAPBIRC2 | |
| SCHEMBL7763429 | 0.71 | MEN1 (0.41) | — | |
| SCHEMBL5663890 | 0.71 | LOXL2 (0.38) | NOS2NOS3NOS1 | |
| SCHEMBL11065856 | 0.70 | NOS2 (0.45) | BACE1NOS2NOS3APPNOS1 | |
| SCHEMBL15295454 | 0.69 | BACE1 (0.44) | BACE1MAPTNOS2NOS3APP | |
| SCHEMBL6369215 | 0.69 | KDM4E (0.37) | KDM4E | |
| SCHEMBL5345645 | 0.69 | XIAP (0.38) | BACE1KDM4EMAPTMCHR1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |