Known targets — ChEMBL curated mechanism
PDE4APDE4BPDE4CPDE4DPDE7APDE7BPDE8APDE8B
The experimentally established mechanism targets of Flavoxate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.90 |
| ▸ | LMNA | P02545 | 5/20 | 0.90 |
| ▸ | HTR1A | P08908 | 3/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.90 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.90 |
| ▸ | ACHE | P22303 | 1/20 | 0.90 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.90 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.90 |
| ▸ | DRD3 | P35462 | 1/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.90 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.90 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flavoxate SCHEMBL29421720 | 0.95 | LMNA (1.00) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| Flavoxate SCHEMBL25801 | 0.95 | LMNA (1.00) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| Flavoxate SCHEMBL124540 | 0.94 | LMNA (0.98) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| Flavoxate SCHEMBL29395220 | 0.94 | LMNA (0.98) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| Flavoxate SCHEMBL1650335 | 0.93 | LMNA (0.96) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL10549683 | 0.87 | LMNA (0.85) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| SCHEMBL10707910 | 0.87 | LMNA (0.84) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL11035366 | 0.86 | LMNA (0.83) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL10709825 | 0.86 | LMNA (0.83) | LMNAHTR1AADRA1AKDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL10710690 | 0.84 | LMNA (0.80) | LMNAHTR1AADRA1AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030203899-A1 | Drugs for incontinence | NICOX S.A. (FR) | 2003-10-30 | — | — | US | disclosed |
| EP-1307184-A2 | DRUGS FOR INCONTINENCE | NICOX S.A. (FR) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002011707-A2 | DRUGS FOR INCONTINENCE | NICOX S.A. (FR) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203899-A1 | Drugs for incontinence | PDE3A, NOS1, PDE3B | PDE4A 24/4885LMNA 2915/4885HTR1A 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.