Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pinacidil Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 known ✓ | O60706 | 3/20 | 0.49 |
| ▸ | KCNJ11 known ✓ | Q14654 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 10/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pinacidil Anhydrous SCHEMBL2131822 | 0.92 | ABCC9 (0.56) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA | |
| Pinacidil Anhydrous SCHEMBL810974 | 0.92 | ABCC9 (0.56) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA | |
| Pinacidil Anhydrous SCHEMBL9275528 | 0.92 | ABCC9 (0.56) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA | |
| SCHEMBL9296867 | 0.83 | KMT2A (0.42) | ALDH1A1LMNAMAPK1GLANPSR1 | |
| SCHEMBL9456838 | 0.77 | ABCC9 (0.51) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA | |
| SCHEMBL12136940 | 0.77 | ABCC9 (0.49) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA | |
| Pinacidil Anhydrous SCHEMBL7061536 | 0.77 | ABCC9 (0.46) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA | |
| SCHEMBL10446808 | 0.76 | KCNJ11 (0.41) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA | |
| Naminidil SCHEMBL7629417 | 0.76 | ABCC9 (0.56) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA | |
| Naminidil SCHEMBL7628139 | 0.76 | ABCC9 (0.56) | ALDH1A1ABCC9KCNJ11CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030203899-A1 | Drugs for incontinence | NICOX S.A. (FR) | 2003-10-30 | — | — | US | disclosed |
| EP-1307184-A2 | DRUGS FOR INCONTINENCE | NICOX S.A. (FR) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002011707-A2 | DRUGS FOR INCONTINENCE | NICOX S.A. (FR) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203899-A1 | Drugs for incontinence | PDE3A, NOS1, PDE3B | ABCC9 454/4885KCNJ11 1628/4885ALDH1A1 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.