Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pinacidil Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 known ✓ | O60706 | 3/20 | 0.56 |
| ▸ | KCNJ11 known ✓ | Q14654 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pinacidil Anhydrous SCHEMBL9275528 | 1.00 | ABCC9 (0.56) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| Pinacidil Anhydrous SCHEMBL2131829 | 1.00 | ABCC9 (0.56) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| Pinacidil Anhydrous SCHEMBL65788 | 1.00 | ABCC9 (0.56) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| Pinacidil Anhydrous SCHEMBL2131822 | 1.00 | ABCC9 (0.56) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| Pinacidil Anhydrous SCHEMBL9271625 | 1.00 | ABCC9 (0.56) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| Pinacidil Anhydrous SCHEMBL7061537 | 0.92 | ALDH1A1 (0.49) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| SCHEMBL9456838 | 0.84 | ABCC9 (0.51) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| Naminidil SCHEMBL7628146 | 0.83 | ABCC9 (0.56) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| SCHEMBL10446808 | 0.83 | KCNJ11 (0.41) | ABCC9KCNJ11CYP3A4LMNAMAPK1 | |
| Naminidil SCHEMBL1159568 | 0.83 | ABCC9 (0.56) | ABCC9KCNJ11CYP3A4LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120100229-A1 | Treatment and Prevention of White Matter Injury with KATP Channel Activators | YALE UNIVERSITY | 2012-04-26 | — | — | US | claimed |
| WO-2010111518-A1 | TREATMENT AND PREVENTION OF WHITE MATTER INJURY WITH KATP CHANNEL ACTIVATORS | YALE UNIVERSITY (US) | 2010-09-30 | — | — | WO | claimed |
| US-5244664-A | Hair growth | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1993-09-14 | — | — | US | claimed |
| EP-0398945-B1 | NEW TOPICAL PREPARATION FOR TREATMENT OF ALOPECIA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1993-05-12 | — | — | EP | claimed |
| WO-1989010757-A1 | NEW OPHTHALMIC PREPARATION FOR TREATING GLAUCOMA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LØVENS KEMIS (DK) | 1989-11-16 | — | — | WO | claimed |
| WO-1989006530-A1 | NEW TOPICAL PREPARATION FOR TREATMENT OF ALOPECIA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LØVENS KEMIS (DK) | 1989-07-27 | — | — | WO | claimed |
| US-4409222-A | Pinacidil-diuretic preparation for treating hypertension or congestive heart failure | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKI FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1983-10-11 | — | — | US | claimed |
| US-RE31244-E | Antihypertensive pyridylguanidine compounds | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1983-05-17 | — | — | US | claimed |
| JP-5255087-A | — | — | None | — | — | JP | disclosed |
| JP-60004120-A | — | — | None | — | — | JP | disclosed |
| EP-2894149-B1 | Cyanoguanidine prodrugs | LEO PHARMA AS (DK) | 2017-08-02 | — | — | EP | disclosed |
| US-9393266-B2 | Bacterial extracts cultured in thermal waters for reducing bags and/or dark circles around the eyes | L'OREAL (FR) | 2016-07-19 | — | — | US | disclosed |
| EP-1838696-B1 | NOVEL CYANOGUANIDINE COMPOUNDS | LEO PHARMA AS (DK) | 2016-03-09 | — | — | EP | disclosed |
| EP-1339686-B1 | CYANOGUANIDINE PRODRUGS | LEO PHARMA AS (DK) | 2015-09-16 | — | — | EP | disclosed |
| US-4600577-A | HYPOTENS&VE AGENTS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELKAB) (DK) | 1986-07-15 | — | — | US | disclosed |
| US-4600577-A | HYPOTENS&VE AGENTS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELKAB) (DK) | 1986-07-15 | — | — | US | disclosed |
| JP-S604120-A | PHARMACEUTICAL PREPARATION OF PINACIDIL OF LONG ACTING TYPE | SHIONOGI & CO LTD | 1985-01-10 | — | — | JP | disclosed |
| US-4409222-A | Pinacidil-diuretic preparation for treating hypertension or congestive heart failure | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKI FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1983-10-11 | — | — | US | disclosed |
| US-4409222-A | Pinacidil-diuretic preparation for treating hypertension or congestive heart failure | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKI FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1983-10-11 | — | — | US | disclosed |
| US-RE31244-E | Antihypertensive pyridylguanidine compounds | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1983-05-17 | — | — | US | disclosed |