Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 5/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SDHB | P21912 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262672 | 0.87 | ADORA2A (0.78) | ADORA2AADORA1ABCC1ABCG2TLR7 | |
| SCHEMBL3969700 | 0.84 | KDM4E (0.59) | ADORA2AADORA1KDM4EPDE5AABCC1 | |
| SCHEMBL6797310 | 0.83 | ADORA2A (0.47) | ADORA2AADORA1KDM4EPDE5AABCC1 | |
| SCHEMBL7226777 | 0.83 | ADORA2A (1.00) | ADORA2AADORA1TLR7IGF1RMAPT | |
| SCHEMBL6797446 | 0.81 | POLB (0.46) | ADORA2AADORA1KDM4EPDE5AABCC1 | |
| SCHEMBL6481272 | 0.81 | KDM4E (0.47) | ADORA2AADORA1KDM4EPDE5AABCC1 | |
| SCHEMBL6478698 | 0.80 | KDM4E (0.44) | ADORA2AADORA1KDM4EPDE5AABCC1 | |
| SCHEMBL6211915 | 0.77 | ADAM17 (0.53) | KDM4EPDE5AABCC1ABCG2TLR7 | |
| SCHEMBL6632655 | 0.77 | ADORA2A (0.57) | ADORA2AADORA1TLR7IGF1RMAPT | |
| SCHEMBL8441818 | 0.74 | ADORA2A (0.71) | ADORA2AADORA1TLR7IGF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6740649-B2 | ANTIINFLAMMATORY AGENTS; OSTEOPOROSIS | BRISTOL-MYERS SQUIBB COMPANY | 2004-05-25 | — | — | US | disclosed |
| US-20030139388-A1 | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE) | BRISTOL-MYERS SQUIBB COMPANY (FORMERLY D/B/A DUPONT PHARMACEUTICALS COMPANY) | 2003-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139388-A1 | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE) | ADAMTS1, MMP1, ADAM17 | ADORA2A 4293/4885ADORA1 2212/4885KDM4E 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.