Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6835624 | 0.86 | NOTUM (0.47) | NOTUMCHRM4MGLL | |
| SCHEMBL7065088 | 0.86 | NOTUM (0.45) | GRM5CYP1A2NOTUMHRH2HRH1 | |
| SCHEMBL6988588 | 0.85 | NOTUM (0.45) | GRM5CYP1A2NOTUMHRH2HRH1 | |
| SCHEMBL7062266 | 0.79 | NOTUM (0.43) | GRM5CYP1A2NOTUMCHRM4MGLL | |
| SCHEMBL6985886 | 0.77 | NOTUM (0.60) | NOTUMCHRM4MGLLHRH3DRD2 | |
| SCHEMBL14632427 | 0.75 | NOTUM (0.57) | NOTUMMGLLHRH3DRD2 | |
| SCHEMBL6988378 | 0.75 | NOTUM (0.57) | NOTUMMGLLHRH3DRD2 | |
| SCHEMBL14632375 | 0.74 | NOTUM (0.56) | NOTUMMGLLHRH3DRD2 | |
| SCHEMBL6839819 | 0.74 | NOTUM (0.56) | NOTUMMGLLHRH3DRD2 | |
| SCHEMBL6839730 | 0.73 | DRD2 (0.52) | NOTUMDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030176465-A1 | Cyclic amino acid derivatives | MERCK PATENT GMBH (DE) | 2003-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176465-A1 | Cyclic amino acid derivatives | F5, F11, F2 | GRM5 1045/4885CYP1A2 4258/4885NOTUM 4067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.