Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PDE7A | Q13946 | 12/20 | 0.51 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.51 |
| ▸ | USP7 | Q93009 | 4/20 | 0.50 |
| ▸ | USP47 | Q96K76 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5880619 | 0.82 | PDE7A (0.69) | IDO1TSHRMAPK1PDE7APDE7B | |
| SCHEMBL12273009 | 0.78 | ALDH1A1 (0.50) | PDE7AUSP7USP47ALDH1A1LMNA | |
| SCHEMBL7606433 | 0.77 | TSHR (0.61) | IDO1TSHRMAPK1PDE7APDE7B | |
| SCHEMBL7641381 | 0.77 | PDE7A (0.55) | IDO1TSHRMAPK1PDE7APDE7B | |
| SCHEMBL7607770 | 0.76 | IDO1 (0.63) | IDO1TSHRMAPK1PDE7APDE7B | |
| SCHEMBL12491961 | 0.73 | ALDH1A1 (0.46) | PDE7AUSP7USP47ALDH1A1LMNA | |
| SCHEMBL7605579 | 0.73 | PDE7A (0.67) | IDO1TSHRMAPK1PDE7APDE7B | |
| SCHEMBL7069272 | 0.73 | ITGB2 (0.54) | TSHRMAPK1PDE7AALDH1A1MEN1 | |
| SCHEMBL30559692 | 0.73 | ALDH1A1 (0.54) | TSHRMAPK1USP7USP47ALDH1A1 | |
| SCHEMBL6556643 | 0.73 | ALDH1A1 (0.54) | TSHRMAPK1USP7USP47ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968180-B1 | SUBSTITUTED DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLOOXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2003-06-04 | — | — | EP | disclosed |
| US-6297282-B1 | TREATING INFLAMMATION AND PAIN | NYCOMED AUSTRIA GMBH (AT) | 2001-10-02 | — | — | US | disclosed |