Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | IDO1 | P14902 | 1/20 | 0.60 |
| ▸ | USP7 | Q93009 | 3/20 | 0.53 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 13/20 | 0.51 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.47 |
| ▸ | ITGAL | P20701 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610147 | 0.83 | IDO1 (0.53) | TSHRMAPK1IDO1USP7USP47 | |
| SCHEMBL7607770 | 0.83 | IDO1 (0.63) | TSHRMAPK1IDO1USP7USP47 | |
| SCHEMBL5880619 | 0.83 | PDE7A (0.69) | TSHRMAPK1IDO1USP7USP47 | |
| SCHEMBL7605579 | 0.80 | PDE7A (0.67) | TSHRMAPK1IDO1USP7USP47 | |
| SCHEMBL7065384 | 0.77 | IDO1 (0.53) | TSHRMAPK1IDO1USP7USP47 | |
| SCHEMBL7611550 | 0.77 | PDE7A (0.72) | IDO1PDE7APDE7BPDE4BPDE4D | |
| SCHEMBL29398960 | 0.77 | TSHR (1.00) | TSHRMAPK1IDO1PDE7APDE7B | |
| SCHEMBL487215 | 0.77 | TSHR (1.00) | TSHRMAPK1IDO1PDE7APDE7B | |
| SCHEMBL3165346 | 0.76 | ITGB2 (0.72) | TSHRMAPK1IDO1PDE7AITGB2 | |
| SCHEMBL296924 | 0.76 | IDO1 (1.00) | TSHRMAPK1IDO1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |