Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21311814 | 0.77 | ALDH1A1 (0.46) | ALDH1A1GAALMNAHSD17B10MEN1 | |
| SCHEMBL2417510 | 0.77 | ALDH1A1 (0.30) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11872285 | 0.72 | ALDH1A1 (0.36) | ALDH1A1GAALMNAHSD17B10MEN1 | |
| SCHEMBL21884140 | 0.71 | ALOX15 (0.41) | ALDH1A1GAALMNAHSD17B10MEN1 | |
| SCHEMBL28536541 | 0.69 | ALDH1A1 (0.37) | ALDH1A1GAALMNAHSD17B10MEN1 | |
| SCHEMBL7066093 | 0.69 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL10292049 | 0.69 | ALDH1A1 (0.46) | CHRM2CHRM4CHRM5CHRM1CHRNB2 | |
| SCHEMBL13479942 | 0.68 | CHRNB2 (0.45) | CHRM2CHRM4CHRM5CHRM1CHRNB2 | |
| SCHEMBL9253651 | 0.68 | ALDH1A1 (0.39) | CHRM2CHRM4CHRM5CHRM1CHRNB2 | |
| SCHEMBL20870669 | 0.68 | ALDH1A1 (0.50) | CHRM2CHRM4CHRM5CHRM1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028721-B1 | N,N'-BIS(SULFONYL)HYDRAZINES USEFUL AS ANTINEOPLASTIC AGENTS | UNIV YALE (US) | 2003-06-04 | — | — | EP | disclosed |
| US-6040338-A | N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents | YALE UNIVERSITY (US) | 2000-03-21 | — | — | US | disclosed |