Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088530 | 0.92 | GRIN1 (0.42) | GRIN1GRIN2BLMNAMAOASLC6A2 | |
| SCHEMBL6086617 | 0.90 | GRIN1 (0.39) | GRIN1GRIN2BLMNAMAOASLC6A2 | |
| SCHEMBL7074091 | 0.90 | GRIN1 (0.39) | GRIN1GRIN2BMEN1ALDH1A1CYP3A4 | |
| SCHEMBL6088065 | 0.89 | GRIN1 (0.38) | GRIN1GRIN2BMEN1ALDH1A1CYP3A4 | |
| SCHEMBL7071444 | 0.89 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL6086495 | 0.86 | LMNA (0.35) | GRIN1GRIN2BLMNAMAOASLC6A2 | |
| SCHEMBL7850057 | 0.84 | GRIN1 (0.37) | GRIN1GRIN2BMEN1ALDH1A1CYP3A4 | |
| SCHEMBL7070522 | 0.84 | GRIN1 (0.35) | GRIN1GRIN2BLMNAMAOASLC6A2 | |
| SCHEMBL12829055 | 0.83 | MAOB (0.36) | LMNAMEN1ALDH1A1CYP3A4KMT2A | |
| SCHEMBL7854164 | 0.82 | GRIN1 (0.34) | GRIN1GRIN2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0827498-B1 | NEW ANTIVIRAL SUBSTITUTED PYRIMIDINEDIONE HOMOCARBOCYCLIC NUCLEOSIDE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME AS ACTIVE INGREDIENTS | SAMJIN PHARM CO LTD (KR) | 2003-06-18 | — | — | EP | disclosed |
| US-5922727-A | 1-((SUBSTITUTED)CYCLOALK(EN)YLALKYL)-6-((SUB)PHENYL(CARBONYL, SULFIDE, OR OXO))-2,4-PYRIMIDINEDIONE DERIVATIVES HAVING SUPERIOR ANTIVIRAL ACTIVITIES; HIV | SAMJIN PHARMACEUTICAL CO., LTD (KR) | 1999-07-13 | — | — | US | disclosed |