Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18301525 | 0.89 | SLC7A5 (0.43) | SLC7A5PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL27563969 | 0.83 | CTSS (0.40) | SLC7A5PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL7251795 | 0.83 | F2 (0.40) | SLC7A5PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL7244994 | 0.83 | F2 (0.40) | SLC7A5PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL23038616 | 0.83 | SLC7A5 (0.37) | SLC7A5PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL4528518 | 0.82 | CTSS (0.39) | SLC7A5ATML3MBTL1ITGA4ITGB7 | |
| SCHEMBL15577663 | 0.81 | CTSS (0.44) | SLC7A5ITGA4ITGB7ACEPPARG | |
| SCHEMBL6548736 | 0.78 | ITGA4 (0.44) | SLC7A5ATML3MBTL1ITGA4ITGB7 | |
| SCHEMBL7970300 | 0.77 | SLC7A5 (0.44) | SLC7A5ATML3MBTL1ITGA4ITGB7 | |
| SCHEMBL8392929 | 0.77 | ATM (0.45) | SLC7A5ATML3MBTL1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966439-B1 | CERTAIN CYCLIC THIO SUBSTITUTED ACYLAMINOACID AMIDE DERIVATIVES | NOVARTIS AG (CH) | 2003-06-04 | — | — | EP | disclosed |
| US-6201133-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS, TREATING TNF ALPHA AND MATRIX METALLOPROTEINASE DEPENDENT DISEASES OR CONDITIONS, CANCER | NOVARTIS AG (CH) | 2001-03-13 | — | — | US | disclosed |
| US-6034136-A | METALLOPROTEINASE INHIBITOR | NOVARTIS AG (CH) | 2000-03-07 | — | — | US | disclosed |
| EP-0966439-A1 | CERTAIN CYCLIC THIO SUBSTITUTED ACYLAMINOACID AMIDE DERIVATIVES | Novartis AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998042662-A1 | CERTAIN CYCLIC THIO SUBSTITUTED ACYLAMINOACID AMIDE DERIVATIVES | NOVARTIS AG (CH) | 1998-10-01 | — | — | WO | disclosed |