Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 8/20 | 0.33 |
| ▸ | GSK3B | P49841 | 8/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1194126 | 0.87 | MAPK8 (0.38) | KMT2AAPOBEC3AAPOBEC3GALDH1A1CYP2D6 | |
| SCHEMBL6597480 | 0.86 | MAPK8 (0.39) | KMT2AAPOBEC3AAPOBEC3GNPY5RALDH1A1 | |
| Hydrochloric Acid SCHEMBL1193657 | 0.85 | KMT2A (0.44) | KMT2AAPOBEC3AAPOBEC3GALDH1A1KDM4E | |
| SCHEMBL6598021 | 0.83 | KMT2A (0.45) | KMT2AAPOBEC3AAPOBEC3GALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL6611866 | 0.80 | POLB (0.38) | KMT2AALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL6599056 | 0.76 | CYP3A4 (0.39) | KMT2AAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL5364641 | 0.76 | KMT2A (0.35) | KMT2AAPOBEC3AAPOBEC3GKDM4ECYP2D6 | |
| SCHEMBL6618821 | 0.74 | MAPT (0.36) | KMT2AALDH1A1KDM4ELMNARAB9A | |
| SCHEMBL6598418 | 0.74 | KMT2A (0.36) | KMT2AAPOBEC3AAPOBEC3GKDM4ECYP2D6 | |
| Bromide SCHEMBL1194131 | 0.74 | KMT2A (0.35) | KMT2AAPOBEC3AAPOBEC3GKDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030045554-A1 | Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof | TORRENT PHARMACEUTICALS LTD. | 2003-03-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045554-A1 | Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof | AGER, GLA, F12 | KMT2A 3588/4885APOBEC3A 1017/4885APOBEC3G 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.