Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475216 | 0.94 | KDM4E (0.48) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL21590293 | 0.83 | DRD4 (0.50) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL14004242 | 0.81 | ALDH1A1 (0.56) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL72837 | 0.81 | LSS (0.56) | ALDH1A1LTA4HMAPK1HRH1 | |
| SCHEMBL6557649 | 0.79 | MAOB (0.57) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL7330936 | 0.79 | CYP2D6 (0.63) | KDM4EDRD4DRD2DRD3LTA4H | |
| SCHEMBL27536116 | 0.79 | DRD4 (0.47) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL4089033 | 0.79 | DRD4 (0.51) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL9155411 | 0.79 | MAPT (0.55) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL11039418 | 0.79 | ATM (0.50) | KDM4EALDH1A1DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319004-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | claimed |
| WO-2002024701-A2 | SUBSTITUTED AZEPINO[4,5B)INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | claimed |